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. 2023 Feb 23;14:1007624. doi: 10.3389/fimmu.2023.1007624

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Copyright © 2023 Zhou, Sun, Tang, Yuan, Wang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Based on the STRING database, 26 key genes were identified based on the two PPI network analysis in RA and MDD. (A) The left PPI network A is composed of genes in RA-MEyellow module and MDD-MEturquoise module (degree shown by node size). (B) The right PPI network B is composed of genes in RA-MEyellow module and MDD-MEblue module (degree shown by node size). (C) Screening of 17 key genes in the left PPI network A based on ShortestPath, Betweenness, Closeness, and Degree. (D) Screening of 22 key genes in the right PPI network B based on ShortestPath, Betweenness, Closeness, and Degree.