Table 2.

Comparison of estimated mean depressive symptom scores (PHQ-2) for mid-March to mid-September 2019–2022.

Calendar weeks	cw 11-37 2019			cw 11-37 2020			cw 11-37 2019 vs.cw 11-37 2020	cw 11-37 2021			cw 11-37 2019 vs.cw 11-37 2021	cw 11-37 2020 vs.cw 11-37 2021	cw 11-24 2022			cw 11-37 2019 vs.cw 11-24 2022	cw 11-37 2020 vs.cw 11-24 2022	cw 11-37 2021 vs.cw 11-24 2022
Outcome	Mean	95%-CI		Mean	95%-CI		P -value	Mean	95%-CI		P -values		Mean	95%-CI		P -values
Total	0.96	0.90	1.01	0.86	0.81	0.90	0.007	1.11	1.05	1.17	0.000	0.000	1.26	1.20	1.32	0.000	0.000	0.000
Sex
Male	0.93	0.85	1.01	0.78	0.71	0.85	0.006	1.00	0.92	1.09	0.181	0.000	1.19	1.10	1.28	0.000	0.000	0.003
Female	1.00	0.92	1.08	0.94	0.87	1.01	0.291	1.22	1.13	1.32	0.001	0.000	1.33	1.26	1.41	0.000	0.000	0.084
Age
18–29	1.12	0.91	1.33	1.10	0.95	1.26	0.917	1.30	1.06	1.54	0.256	0.172	1.35	1.18	1.52	0.089	0.034	0.733
30–44	0.89	0.75	1.03	0.77	0.64	0.89	0.205	1.21	1.02	1.40	0.007	0.000	1.09	0.95	1.23	0.044	0.001	0.302
45–64	1.09	0.98	1.19	0.91	0.82	1.00	0.011	1.07	0.96	1.17	0.797	0.026	1.37	1.26	1.47	0.000	0.000	0.000
65+	0.80	0.71	0.89	0.73	0.65	0.81	0.267	0.94	0.86	1.02	0.022	0.000	1.15	1.07	1.24	0.000	0.000	0.000
Level of education
Low	1.20	1.05	1.35	1.02	0.91	1.14	0.074	1.33	1.16	1.50	0.264	0.005	1.45	1.31	1.58	0.015	0.000	0.283
Middle	0.91	0.84	0.98	0.81	0.75	0.87	0.033	1.02	0.94	1.09	0.038	0.000	1.20	1.12	1.27	0.000	0.000	0.001
High	0.68	0.62	0.74	0.66	0.58	0.74	0.784	0.87	0.81	0.94	0.000	0.000	0.98	0.92	1.04	0.000	0.000	0.014

Time periods: mid-March to mid-September 2019–2021 (CW 11-37) and mid-March to mid-June (CW 11-24) 2022. Calculation of estimates as well as p-values for comparisons between time periods detailed in section 2.4.2 in Methods. Estimates for each sociodemographic characteristic subgroup are standardized for the respective other two characteristics (e.g., estimates for women standardized for age and level of education). p-values for pairwise comparisons only reported in case of significant joint tests (Supplementary Table A1).