FIGURE 1.

The three digital ingredients. Digital twin, tele-cognitive-rehabilitation, and metaverse are digital ingredients that can improve per se cognitive rehabilitation outcomes in MS. In the beginning, data from tele-cognitive-assessment with dedicated apps implementing validated cognitive tests would allow the cognitive phenotyping of PwMS at group-level; over time, based on an increasing amount of data the AI algorithms would provide a rough cognitive virtual patient’s copy. Asynchronous and, especially, synchronous remote interventions can be delivered through tele-cognitive-rehabilitation; the availability of digital tools for remote communication allowed overcoming barriers that limit the CR access to many PwMS and, consequently, starting the treatments as soon as possible and continuing them during the different disease phases. Metaverse makes available virtual scenarios in which PwMS can actually train in ecological environments a plethora of dual- and multi-tasks and everyday life activities. This figure has been designed using modified free images from Flaticon.com.