Table 2.
Independent hits associated with SA and replicated in 23andMe
| SNP | CHR | BP | A1 | A2 | P_23&me | BETAa | SEa | P_META | Signal source |
|---|---|---|---|---|---|---|---|---|---|
| rs1537818 | 1 | 39647038 | G | A | 2.76E−05 | −0.01755 | 0.004182 | 1.31E−09 | MTAG |
| rs633715 | 1 | 177852580 | T | C | 4.60E−07 | −0.02466 | 0.004898 | 3.49E−08 | MTAG_BMIadj |
| rs72902175 | 2 | 157013035 | T | C | 9.30E−10 | 0.035999 | 0.005866 | 3.67E−14 | MTAG |
| rs1403848 | 3 | 77609655 | C | A | 7.51E−05 | −0.01569 | 0.003962 | 9.30E−09 | MTAG |
| rs4076077 | 5 | 170863509 | T | C | 3.70E−06 | −0.01797 | 0.003882 | 4.26E−09 | MTAG |
| rs1428381 | 5 | 122693901 | G | A | 0.000369 | 0.015265 | 0.004283 | 4.83E−09 | MTAG |
| rs2715039 | 7 | 84094964 | C | A | 4.61E−05 | −0.01611 | 0.003952 | 2.04E−08 | MTAG |
| rs7005777 | 8 | 78233600 | T | G | 5.18E−05 | 0.017513 | 0.00433 | 1.12E−08 | MTAG |
| rs8176749 | 9 | 136131188 | T | C | 1.47E−05 | −0.03212 | 0.007433 | 3.78E−09 | MTAG |
| rs10756798 | 9 | 16739763 | T | C | 3.70E−09 | −0.02425 | 0.004115 | 3.28E−08 | MTAG_BMIadj |
| rs1444789 | 10 | 9064361 | T | C | 2.40E−13 | −0.03701 | 0.005042 | 1.10E−09 | MTAG |
| rs6265 | 11 | 27679916 | T | C | 1.12E−05 | −0.02198 | 0.00501 | 1.79E−14 | MTAG |
| rs1815739 | 11 | 66328095 | T | C | 1.19E−06 | 0.018979 | 0.003906 | 2.10E−08 | MTAG |
| rs4923536 | 11 | 28422496 | G | A | 1.52E−10 | 0.025071 | 0.003915 | 7.51E−11 | MTAG_BMIadj |
| rs28758996 | 12 | 121960480 | G | A | 0.00122 | −0.01282 | 0.003963 | 1.21E−08 | META |
| rs1389799 | 12 | 65824846 | G | A | 3.57E−25 | 0.04184 | 0.004032 | 1.38E−18 | MTAG_BMIadj |
| rs4554968 | 12 | 4372609 | G | A | 0.000854 | 0.013381 | 0.004011 | 4.47E−08 | MTAG_BMIadj |
| rs592333 | 13 | 51340315 | G | A | 9.04E−23 | −0.03997 | 0.004068 | 1.69E−14 | MTAG |
| rs11852496 | 15 | 83817559 | T | C | 3.17E−05 | −0.01918 | 0.004605 | 1.71E−06 | META |
| rs11634019 | 15 | 76634680 | T | C | 4.44E−10 | 0.027288 | 0.00438 | 1.84E−09 | MTAG |
| rs11075985 | 16 | 53805207 | C | A | 1.13E−05 | 0.017161 | 0.003907 | 5.41E−20 | META |
| rs8045335 | 16 | 60607116 | G | A | 1.41E−09 | −0.02374 | 0.003922 | 1.24E−08 | MTAG |
| rs9933881 | 16 | 1740691 | T | C | 3.68E−07 | −0.03664 | 0.007183 | 2.54E−08 | MTAG |
| rs12603115 | 17 | 46248994 | T | C | 3.95E−06 | −0.01812 | 0.003926 | 8.14E−10 | MTAG |
| rs227731 | 17 | 54773238 | T | G | 2.40E−11 | −0.02603 | 0.003896 | 3.96E−09 | MTAG |
| rs4987719 | 18 | 60960310 | T | C | 1.28E−08 | 0.061095 | 0.01068 | 4.72E−09 | MTAG |
| rs35445111 | 19 | 32172047 | G | A | 2.62E−12 | 0.04751 | 0.006817 | 1.62E−11 | MTAG |
| rs6113592 | 20 | 22229505 | G | A | 6.42E−07 | 0.019892 | 0.003998 | 7.82E−11 | MTAG |
| rs6038517 | 20 | 6458205 | G | A | 0.000217 | −0.01703 | 0.0046 | 2.19E−08 | MTAG |
GWAS and replication significant SNPs. Results are shown for variants with genome-wide evidence of association (p < 5e−8) in at least one of the main analyses, and evidence of replication in 23andMe. Abbreviations: META, sleep apnea meta-analysis; MTAG, sleep apnea plus snoring MTAG. MTAG_BMIadj, sleep apnea plus snoring MTAG adjusting for BMI using mtCOJO.
aInformation based on the 23andMe GWAS.