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. 2023 Feb 23;14:1137332. doi: 10.3389/fimmu.2023.1137332

Figure 6.

Figure 6

Inhibition of HDAC8 prevents M2 macrophage polarization via suppressing STAT6 and PI3K/Akt signaling pathways in the high glucose PDF-injured peritoneum (A) Western blot analysis showed the protein levels of CD163, Arg-1 and GAPDH in peritoneum of mice. (B) Western blot analysis showed the protein levels of p-STAT6, STAT6, p-PI3K, PI3K p-Akt, Akt and GAPDH in peritoneum of mice. Expression levels of (C) CD163, (D) Arg-1, (E) p-STAT6, (F) STAT6, (G) p-PI3K, (H) PI3K, (I) p-Akt, (J) Akt were quantified by densitometry and normalized with GAPDH, STAT6, PI3K and Akt respectively. Data were expressed as means ± SEM. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. N.S., statistically not significant, with the comparisons labeled.