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. 2023 Feb 23;11:1139378. doi: 10.3389/fped.2023.1139378

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© 2023 Chin, Kitase, Madurai, Robinson and Jantzie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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White matter microstructure alterations in POE: groupwise comparison of diffusion tensor metrics. Diffusion tensor metrics assess permeability to water flow (diffusivity) along (axial) vs. perpendicular to (radial) white matter tracts. Metrics were examined in two regions of interest (ROIs): corpus callosum (left column: A,C,E) and external capsule (right column: B,D,F). In each plot, individual values (black circles [Saline] vs. gray triangles [POE]) are plotted as well as group statistics (mean ± SEM). Fractional anisotropy (FA; A,B) can be considered a measure of microstructural flow selectivity (near one when axial diffusivity [AD] >> radial diffusivity [RD]; near zero when AD ≈ RD). Note that FA is decreased in POE in both ROIs. This appears to be attributable to decreased AD and increased RD in both ROIs, though differences are most statistically significant for AD in external capsule and for RD in corpus callosum.