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Structural organization of the family of human ADAMs. ADAMs are divided in transmembrane and soluble subgroups. The conserved active site of amino acids is indicated by a black circle. X stands for ADAMs without a conserved active site sequence in their M domain. C, cysteine-rich; CT, cytoplasmic tail; DIS, disintegrin-like; EGF, epidermal growth factor-like; M, metalloproteinase; Pro, prodomain, and SS, signal sequence.
