FIGURE 3.

Illustration of the domains of human ADAM8. On the plasma membrane, the active human ADAM8 comprises a motif associated with ${Zn}^{2+}$ ions within the catalytic domain, that is, essential for the functionality (top image). There is also a motif for binding of a Ca²⁺ ion in the M domain and even two more in the DIS domain. Protein domains are schematically drawn, and amino acid positions are indicated below (bottom image). The domains are drawn in their sequential order by providing the amino acid numbers for the domains (bottom image). Domain name abbreviations are as follows: C, cysteine-rich; CT , cytoplasmic tail; DIS, disintegrin-like; EGF, epidermal growth factor-like; M, metalloproteinase; Pro, prodomain; SS, signal sequence and TM transmembrane.