Table 2.
Follow-up data of FH cohort stratified by sex.
| Total (n = 438) | Females (n = 207) | Males (n = 231) | p value | ||||
|---|---|---|---|---|---|---|---|
| Follow-up at Lipid Clinic | |||||||
| Follow-up, y | 12.0 (7.0) | 438 | 12.6 (7.0) | 207 | 11.5 (6.9) | 231 | 0.12 |
| Number of LDL-C measurements, na | 6 (4–9) | 438 | 6 (5–9) | 207 | 5 (4–9) | 231 | <0.05 |
| Prescribed on statins, No. (%) | 381 (87.0) | 438 | 183 (88.4) | 207 | 198 (85.7) | 231 | 0.49 |
| Age at statin start, y | 15.5 (3.6) | 380 | 15.9 (3.4) | 182 | 15.2 (3.7) | 198 | 0.051 |
| Latest lipids | |||||||
| TC, mM | 5.7 (1.7) | 436 | 5.7 (1.6) | 206 | 5.7 (1.7) | 230 | 0.86 |
| LDL-C, mM | 3.9 (1.6) | 438 | 3.9 (1.5) | 207 | 4.0 (1.6) | 231 | 0.44 |
| HDL-C, mM | 1.3 (0.3) | 437 | 1.4 (0.3) | 206 | 1.2 (0.3) | 231 | <0.001 |
| TGb, mM | 0.90 (0.70–1.30) | 432 | 0.90 (0.70–1.10) | 203 | 0.90 (0.70–1.40) | 229 | 0.36 |
| LDL-C burden | |||||||
| 19 years, mM-years | 106.3 (26.3) | 313 | 111.7 (27) | 157 | 100.7 (24.6) | 156 | <0.001 |
| 30 years, mM-years | 166.5 (36.1) | 313 | 175.1 (36.4) | 42 | 156.7 (33.8) | 37 | <0.05 |
Data are presented as mean (SD), unless otherwise stated. Abbreviations: FH, familial hypercholesterolemia; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; LDL-R, the gene encoding low-density lipoprotein receptor; NA, not available; TC, total cholesterol; TG, triglycerides; y, years. Difference between sexes tested by Independent samples t-test for normally distributed data and Mann-Whitney U test for non-normally distributed data, and Chi-Square test for categorical data, statistically significant when p < 0.05.
a
Premature defined as age <55 y in men and <65 y in women.
b
Median (25–75 percentiles).