Table 3.

Linear mixed effects models for LDL-C and estimated LDL-C burden.

	LDL-C, mmol/L			Estimated LDL-C burden, mM-years
	Beta	95% CI	p	Beta	95% CI	p
Sex
Female	–	–		–	–
Male	−0.609	−1.088, −0.130	0.013	−5.680	−9.115, −2.245	0.001
Age
<10 y	–	–		–	–
10–19 y	−1.210	−1.505, −0.915	<0.001	9.590	8.450, 10.731	<0.001
20–29 y	−2.111	−2.475, −1.747	<0.001	10.018	8.462, 11.573	<0.001
≥30 y	−1.667	−2.208, −1.126	<0.001	8.408	6.153, 10.664	<0.001
Sex∗Age
Male ∗ 10–19 y	0.255	−0.155, 0.664	0.223	−2.510	−4.099, −0.921	0.002
Male ∗ 20–29 y	0.696	0.187, 1.205	0.007	−3.095	−5.292, −0.898	0.006
Male ∗ ≥30 y	0.149	−0.629, 0.927	0.707	−4.008	−7.265, −0.752	0.016

We fitted linear mixed effects models by restricted maximum likelihood (REML) with the lmer function in the lme4/lmerTest packages in R, with random slope for age, and random intercept for subject. The outcome variables were LDL-C (in mmol/L) and estimated LDL-C burden (in mM-years), and the exposure variables were sex (male vs. female) and age (categorical variable), as well as their interaction. Abbreviations: CI, confidence interval; LDL-C, low-density lipoprotein cholesterol; y, years.