Table 2.

Interaction coefficients for comparison of slopes for cognitive performance and brain morphometry between CN, MCI, and Dementia groups [estimate ± SD, (CI)].

	MMSE	p-value	ADAS	p-value	RAVLT	p-value	TMT	p-value	DSST	p-value	GM/TIV	p-value
CN	−0.005 ± 0.021	0.827	0.092 ± 0.063	0.148	−0.174 ± 0.082	0.035	2.126 ± 0.649	0.001	−0.616 ± 0.104	3.65e-09	−0.153 ± 0.019	9.24e-16
	[−0.045; 0.036]		[−0.033; 0.216]		[−0.335; −0.012]		[0.854; 3.398]		[−0.820; −0.413]		[−0.190; −0.116]
CN vs.	−0.008 ± 0.024	0.73	−0.070 ± 0.074	0.342	0.064 ± 0.095	0.050	−1.629 ± 0.752	0.030	0.477 ± 0.120	7.91e-05	0.062 ± 0.022	0.005
MCI	[−0.055; 0.039]		[−0.214; 0.075]		[−0.123; 0.251]		[−3.105; −0.153]		[0.240; 0.713]		[0.019; 0.105]
CN vs.	−0.002 ± 0.026	0.929	−0.076 ± 0.080	0.337	0.199 ± 0.103	0.053	−2.383 ± 0.831	0.004	0.943 ± 0.130	6.75e-13	0.106 ± 0.024	7.20e-06
Dementia	[−0.053; 0.049]		[−0.233; 0.080]		[−0.003; 0.401]		[−4.013; −0.753]		[0.688; 1.198]		[0.060; 0.152]

*CI, confidence interval; GM, gray matter; SD, standard deviation; TIV, total intracranial volume. The bold values indicate the significance of the CN slope and the significant difference between CN and MCI slopes as well as CN and Dementia slopes (p < 0.05).