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. 2023 Feb 23;14:943566. doi: 10.3389/fnagi.2022.943566

Table 5.

Structural brain correlates and cognitive functions involved in MMSE, ADAS-cog, and RAVLT.

Test Cognitive functions Relevant brain structures
MMSE
Temporo-spatial orientation
Precuneus
Cortical gray matter
Memory recall
Precuneus
Intracranial arteries
Hippocampus
Cortical gray matter
Concentration
Superior parietal lobule
Cortical gray matter
Language
Pars triangularis
Hippocampus
Caudal middle frontal gyrus
Cortical gray matter
Visuospatial function
Precuneus
Superior parietal lobule
Fusiform gyrus
Caudal middle frontal gyrus
Cortical gray matter
Working memory Precuneus
Intracranial arteries
Hippocampus
Cortical gray matter
ADAS-cog
Temporo-spatial orientation White matter lesions
Memory and new learning:
- Word recall
- Orientation
- Word recognition
- Memorizing test instructions
Mesial temporal lobe
White matter lesions
Inferior lateral ventricles
Hippocampus
Putamen
Amygdala
Entorhinal cortex
Language:
- Commands
- Spoken language ability
- Naming objects / fingers
- Word-finding difficulty
- Comprehension
White matter lesions
Inferior lateral ventricles
Putamen
Hippocampus
Praxis:
- Constructional praxis
- Ideational praxis
White matter lesions
RAVLT Episodic memory White matter lesions
Insula
Inferior lateral ventricles
Mesial temporal lobe
Inferior parietal lobe
Posterior cingulate cortex
Attention Putamen
Inferior lateral ventricles
Mesial temporal lobe
Inferior parietal lobe
Posterior cingulate cortex