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. 2023 Feb 23;14:1133207. doi: 10.3389/fimmu.2023.1133207

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Copyright © 2023 Berz, Boughdad, Vietti-Violi, Digklia, Dromain, Dunet and Duran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune-related thyroiditis in a 50-year-old female with lower leg Meckel-cell carcinoma who developed mediastinal metastatic spread as shown on baseline ¹⁸F-FDG-PET/CT [coronal PET, CT and merged PET/CT images, # (A)]. A thyroid nodule was also present [arrow, fused PET/CT image (A)]. Pembrolizumab (anti-PD-1) was administered. Follow-up 18F-FDG-PET/CT at 6 months showed disappearance of mediastinal disease and decrease in metabolic activity of the thyroid nodule [arrow, fused PET/CT image (B)]. However, a marked increase in thyroid activity was also evident, consistent with a thyroiditis [arrowheads, fused PET/CT image (B)].