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. 2023 Feb 23;14:1133207. doi: 10.3389/fimmu.2023.1133207

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Copyright © 2023 Berz, Boughdad, Vietti-Violi, Digklia, Dromain, Dunet and Duran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune-related orbital myositis in a 43-year-old female with cutaneous melanoma treated with ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1). After 3 cycles of ipilimumab and nivolumab, the patient reported diplopia. (A) On T2-weighted and (B) contrast-enhanced images, orbital edema, abnormal enhancement and thickening of the right medial occulomotor muscle can be seen, consistent with orbital myositis (arrows). (C, D) MRI at 1 month from treatment discontinuation with disappearance of signs of inflammation.