Table 1.

Common Terminology Criteria for Adverse Events (CTCAE) version 6.0 to classify immune irAEs (31).

Grade	Severity and clinical description
1	Mild: asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated.
2	Moderate: minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL.
3	Severe or medically significant but not immediately life-threatening: hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care ADL.
4	Life-threatening consequences: urgent intervention indicated.
5	Death related to the adverse event.

ADL, activity of daily living.