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. 2023 Feb 15;25(4):134. doi: 10.3892/ol.2023.13720

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Role of LPCAT1 in PTX resistance. (A) Viability of MDA-MB-231 and MDA-MB-231/PTX cells after PTX intervention was detected by a Cell Counting Kit-8 assay. (B and C) Proportion of apoptotic cells following treatment with 4 nM PTX was assessed by flow cytometry. (B) Representative plots and (C) quantified results are shown. (D) Enrichment of apoptosis-associated proteins in the cells was determined using western blotting. ***P<0.001 vs. MDA-MB-231; ^###P<0.001 vs. MDA-MB-231/PTX + sh-NC. LPCAT1, lysophosphatidylcholine acyltransferase 1; PTX, paclitaxel; sh, short hairpin; NC, negative control; PI, propidium iodide; FITC-A, fluorescein isothiocyanate-Annexin V.