Enriching the target population for high risk. Using Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial data, panels A, B, and C represent the population aged 55-75 years, the entire population (A), the top 50% risk (B), and the top 25% risk (C). Risk is for all-cancer mortality over 7 years and is based on model incorporating smoking history, body mass index, family history, and demographics.