Table 2.
Hazard ratios (95% confidence intervals) of cancer death comparing Hispanic, Non-Hispanic Asian, and Non-Hispanic Black survivors with Non-Hispanic White survivors overall and by type of SPCs
| SPC, race and ethnicity | No. of SPC | Person months | No. of deaths | Model 1a | Model 2a | Model 3a |
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| All SPCs | ||||||
| Hispanic | 3197 | 144 973 | 1253 | 1.24 (1.17 to 1.31) | 1.14 (1.06 to 1.21) | 1.08 (1.00 to 1.16) |
| Non-Hispanic Asian | 2146 | 113 402.5 | 697 | 0.89 (0.83 to 0.96) | 0.93 (0.85 to 1.01) | 0.92 (0.85 to 1.01) |
| Non-Hispanic Black | 4227 | 182 490.5 | 1874 | 1.46 (1.39 to 1.53) | 1.19 (1.12 to 1.25) | 1.12 (1.05 to 1.19) |
| Non-Hispanic White | 29 459 | 1 437 088.5 | 11 293 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second breast cancerb | ||||||
| Hispanic | 1420 | 75 866 | 424 | 1.54 (1.39 to 1.72) | 1.24 (1.09 to 1.41) | 1.17 (1.01 to 1.35) |
| Non-Hispanic Asian | 879 | 54 737 | 172 | 0.89 (0.76 to 1.04) | 0.90 (0.75 to 1.08) | 0.85 (0.71 to 1.03) |
| Non-Hispanic Black | 1965 | 101 607 | 656 | 1.77 (1.62 to 1.94) | 1.27 (1.14 to 1.42) | 1.28 (1.14 to 1.44) |
| Non-Hispanic White | 9895 | 601 328.5 | 2087 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second lung cancer | ||||||
| Hispanic | 259 | 5914 | 177 | 1.03 (0.89 to 1.20) | 0.92 (0.78 to 1.08) | 0.86 (0.71 to 1.03) |
| Non-Hispanic Asian | 187 | 6181.5 | 112 | 0.76 (0.63 to 0.91) | 0.68 (0.55 to 0.84) | 0.68 (0.54 to 0.85) |
| Non-Hispanic Black | 451 | 10 569.5 | 318 | 1.07 (0.95 to 1.20) | 0.84 (0.74 to 0.95) | 0.81 (0.71 to 0.93) |
| Non-Hispanic White | 4179 | 101 526 | 2928 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second colorectal cancer | ||||||
| Hispanic | 206 | 9725.5 | 74 | 1.14 (0.90 to 1.44) | 1.17 (0.91 to 1.51) | 1.15 (0.88 to 1.52) |
| Non-Hispanic Asian | 187 | 10 696 | 52 | 0.85 (0.64 to 1.12) | 0.95 (0.70 to 1.28) | 0.99 (0.73 to 1.34) |
| Non-Hispanic Black | 391 | 17 925.5 | 155 | 1.40 (1.18 to 1.67) | 1.14 (0.95 to 1.38) | 1.07 (0.87 to 1.31) |
| Non-Hispanic White | 2670 | 137 148 | 957 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second uterine cancer | ||||||
| Hispanic | 167 | 8899 | 46 | 1.28 (0.94 to 1.73) | 1.27 (0.90 to 1.79) | 0.98 (0.66 to 1.44) |
| Non-Hispanic Asian | 166 | 9365 | 42 | 1.07 (0.78 to 1.47) | 1.13 (0.80 to 1.60) | 0.91 (0.61 to 1.36) |
| Non-Hispanic Black | 249 | 11 375.5 | 98 | 1.83 (1.48 to 2.28) | 1.31 (1.02 to 1.68) | 1.25 (0.95 to 1.65) |
| Non-Hispanic White | 1890 | 116 947.5 | 534 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
Model 1 adjusted for age at diagnosis of SPC, year of diagnosis of SPC, and type of SPC (4 cancer groups based on 5-year relative survival rate. This is only for all SPC model); Model 2: Model 1 + tumor stage of SPC, treatment of SPC (surgery, chemotherapy, and radiation therapy), marital status, median household income, percent less than ninth grade, and region of registry at SPC diagnosis; Model 3: Model 2 + age at diagnosis of first breast cancer, tumor stage of first breast cancer, estrogen receptor status of first breast cancer, treatment of first breast cancer (surgery, chemotherapy, and radiation therapy). CI = confidence interval; HR = hazard ratio; SPC = second primary cancer.
Model 2 and 3 further adjusted for estrogen receptor status of the second breast cancer.