Table 3.
Hazard ratios (95% confidence intervals) of death from cardiovascular disease comparing Hispanic, Non-Hispanic Asian, and Non-Hispanic Black to Non-Hispanic White survivors overall and by type of SPCs
| SPC, race and ethnicity | No. of deaths | Model 1a | Model 2a | Model 3a |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||
| All SPCs | ||||
| Hispanic | 97 | 1.12 (0.91 to 1.38) | 1.03 (0.82 to 1.29) | 1.01 (0.78 to 1.29) |
| Non-Hispanic Asian | 61 | 0.83 (0.64 to 1.07) | 0.89 (0.67 to 1.17) | 0.83 (0.61 to 1.13) |
| Non-Hispanic Black | 196 | 1.67 (1.44 to 1.94) | 1.47 (1.25 to 1.74) | 1.44 (1.20 to 1.74) |
| Non-Hispanic White | 1422 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second breast cancerb | ||||
| Hispanic | 36 | 1.04 (0.74 to 1.47) | 0.86 (0.57 to 1.31) | 0.91 (0.58 to 1.42) |
| Non-Hispanic Asian | 19 | 0.64 (0.41 to 1.02) | 0.75 (0.45 to 1.23) | 0.62 (0.35 to 1.12) |
| Non-Hispanic Black | 91 | 1.94 (1.55 to 2.43) | 1.62 (1.25 to 2.09) | 1.74 (1.30 to 2.32) |
| Non-Hispanic White | 479 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second lung cancer | ||||
| Hispanic | 7 | 0.97 (0.45 to 2.06) | 0.99 (0.45 to 2.15) | 0.81 (0.32 to 2.02) |
| Non-Hispanic Asian | 10 | 1.62 (0.85 to 3.08) | 1.80 (0.92 to 3.53) | 1.86 (0.87 to 3.96) |
| Non-Hispanic Black | 24 | 1.80 (1.17 to 2.78) | 1.31 (0.81 to 2.13) | 1.08 (0.61 to 1.92) |
| Non-Hispanic White | 148 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second colorectal cancer | ||||
| Hispanic | 18 | 1.76 (1.08 to 2.86) | 1.60 (0.96 to 2.67) | 1.54 (0.86 to 2.76) |
| Non-Hispanic Asian | 2 | 0.21 (0.05 to 0.86) | 0.20 (0.05 to 0.83) | 0.21 (0.05 to 0.86) |
| Non-Hispanic Black | 27 | 1.52 (1.01 to 2.28) | 1.64 (1.07 to 2.50) | 1.64 (1.02 to 2.64) |
| Non-Hispanic White | 203 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Second uterine cancer | ||||
| Hispanic | 4 | 1.02 (0.37 to 2.78) | 1.16 (0.41 to 3.25) | 0.89 (0.27 to 2.92) |
| Non-Hispanic Asian | 6 | 1.21 (0.53 to 2.78) | 1.33 (0.57 to 3.13) | 0.79 (0.24 to 2.59) |
| Non-Hispanic Black | 3 | 0.43 (0.14 to 1.37) | 0.49 (0.15 to 1.60) | 0.56 (0.17 to 1.83) |
| Non-Hispanic White | 98 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
Model 1 adjusted for age at diagnosis of SPC, year of diagnosis of SPC, and type of SPC (4 cancer groups based on 5-year relative survival rate. This is only for all SPC model); Model 2: Model 1 + tumor stage of SPC, treatment of SPC (surgery, chemotherapy, and radiation therapy), marital status, median household income, percent less than ninth grade, and region of registry at SPC diagnosis; Model 3: Model 2 + age at diagnosis of first breast cancer, tumor stage of first breast cancer, estrogen receptor status of first breast cancer, treatment of first breast cancer (surgery, chemotherapy, and radiation therapy). CI = confidence interval; HR = hazard ratio; SPC = second primary cancer.
Model 2 and 3 further adjusted for estrogen receptor status of the second breast cancer.