Table 4.
Hazard ratios (95% confidence intervals) of death from cancer and cardiovascular disease comparing Hispanic, Non-Hispanic Asian, and Non-Hispanic Black to Non-Hispanic White survivors among women diagnosed with SPCs age 70 years and younger, and older than 70 years of age
| Age, race and ethnicity | No. of SPC | Person-months | Death from cancer |
Death from cardiovascular disease |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of deaths | Model 1a | Model 2a | Model 3a | No. of deaths | Model 1a | Model 2a | Model 3a | |||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |||||
| ≤70 y | ||||||||||
| Hispanic | 2229 | 110 560.5 | 779 | 1.27 (1.18 to 1.37) | 1.10 (1.01 to 1.20) | 1.04 (0.94 to 1.14) | 28 | 1.17 (0.79 to 1.73) | 1.14 (0.76 to 1.73) | 1.03 (0.64 to 1.66) |
| Non-Hispanic Asian | 1481 | 86 278.5 | 420 | 0.88 (0.79 to 0.97) | 0.94 (0.84 to 1.04) | 0.91 (0.81 to 1.02) | 19 | 0.96 (0.60 to 1.52) | 1.08 (0.66 to 1.77) | 1.08 (0.64 to 1.83) |
| Non-Hispanic Black | 2869 | 137 919 | 1190 | 1.56 (1.46 to 1.66) | 1.24 (1.15 to 1.33) | 1.17 (1.08 to 1.26) | 80 | 2.60 (2.02 to 3.35) | 1.85 (1.39 to 2.46) | 1.70 (1.23 to 2.33) |
| Non-Hispanic White | 15 421 | 890 655.5 | 4990 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | 246 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| >70 y | ||||||||||
| Hispanic | 968 | 34 412.5 | 474 | 1.17 (1.07 to 1.29) | 1.15 (1.04 to 1.28) | 1.08 (0.97 to 1.21) | 69 | 1.12 (0.88 to 1.43) | 0.99 (0.76 to 1.30) | 1.01 (0.75 to 1.35) |
| Non-Hispanic Asian | 665 | 27 124 | 277 | 0.90 (0.80 to 1.01) | 0.89 (0.78 to 1.02) | 0.92 (0.80 to 1.06) | 42 | 0.79 (0.58 to 1.08) | 0.84 (0.60 to 1.17) | 0.76 (0.52 to 1.10) |
| Non-Hispanic Black | 1358 | 44 571.5 | 684 | 1.29 (1.19 to 1.40) | 1.12 (1.02 to 1.22) | 1.07 (0.97 to 1.17) | 116 | 1.35 (1.12 to 1.64) | 1.28 (1.04 to 1.58) | 1.31 (1.04 to 1.64) |
| Non-Hispanic White | 14 038 | 546 433 | 6303 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) | 1176 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| P interaction | ||||||||||
| Poverall interactionb | .12 | .07 | ||||||||
| PHispanic*age70c | .51 | .97 | ||||||||
| PNon-Hispanic Asian*age70c | .59 | .46 | ||||||||
| PNon-Hispanic Black*age70c | .02 | .009 | ||||||||
Model 1 adjusted for age at diagnosis of SPC, year of diagnosis of SPC, and type of SPC (4 cancer groups based on 5-year relative survival rate); Model 2: Model 1 + tumor stage of SPC, treatment of SPC (surgery, chemotherapy, and radiation therapy), marital status, median household income, precent ninth grade, and region of registry at SPC diagnosis; Model 3: Model 2 + age at diagnosis of first breast cancer, tumor stage of first breast cancer, estrogen receptor status of first breast cancer, treatment of first breast cancer (surgery, chemotherapy, and radiation therapy). CI = confidence interval; HR = hazard ratio; SPC = second primary cancer.
P value was from the likelihood ratio test comparing Model 3 with interaction between race and ethnicity and age category (70 years and younger vs older than 70 years) with Model 3 without interaction.
P value was for the interaction term between each race and ethnicity and age category (70 years and younger vs older than 70 years) using Model 3.