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Inter-fractional changes of patients with single/multiple lesions. (A) The differences of ΔV, DSC and HD of single and multiple lesions. A * indicates a significance of p < 0.05. (B) The gross tumor volume delineation and 3D projection charts of a multiple lesions patient at planning (Fx0), fraction 1, 2, 3, 4 and 5 (Fx1, Fx2, Fx3, Fx4 and Fx5) on initial CT, illustrating patient-specific serial multiple lesions volume changes and anatomical shifts.
