Fig. 2.

Analysis of duplicate liver biopsies suggests inherent sampling heterogeneity for viral antigens.

(A) Representative images from duplicate biopsies collected from the same participant and time point. Embedded legends indicate markers, corresponding colour, and percent hepatocytes positive for viral antigens. (B) Correlation between % total HBV+ hepatocytes (defined as HBsAg+ and/or HBV core+) in biopsy 1 vs. biopsy 2 from the same participant and time point using Pearson’s correlation analysis. (C) Quantification of total HBV burden when duplicate biopsies are plotted individually (left) or averaged for the same participant and time point (right). (D) Representative image of a large wedge biopsy with regions of low (embedded image 1) and high (embedded image 2) % of HBsAg+ hepatocytes.