Table 1.
Baseline participant population.
| HBeAg+ (n = 39) | HBeAg- (n = 75) | Total cohort (N = 114) | |
|---|---|---|---|
| Baseline demographics | |||
| Age, years | 30 (24, 42) | 47 (39, 54) | 42 (31, 51) |
| Men | 34 (87) | 64 (85) | 98 (86) |
| Women |
5 (13) |
11 (15) |
16 (14) |
| HBV genotype | |||
| A | 6 (15) | 11 (15) | 17 (15) |
| B | 5 (13) | 8 (11) | 13 (11) |
| C | 10 (26) | 6 (8) | 16 (14) |
| D | 16 (41) | 48 (64) | 64 (56) |
| E | 1 (3) | 0 | 1 (1) |
| F | 1 (3) | 0 | 1 (1) |
| G | 0 | 1 (1) | 1 (1) |
| U |
0 |
1 (1) |
1 (1) |
| Baseline peripheral biomarker values | |||
| HBV DNA, log10 IU/ml | 8.0 (7.6, 8.7); n = 39 | 6.0 (5.4, 7.3); n = 69 | 7.1 (5.8, 8.0); n = 108 |
| HBsAg, l log10 IU/ml | 4.6 (4.1, 5.1); n = 39 | 3.8 (3.3, 4.1); n = 70 | 4.0 (3.6, 4.4); n = 109 |
| HBV RNA, log10 IU/ml | 7.0 (6.5, 7.7); n = 28 | 4.8 (4.2, 5.7); n = 45 | 5.7 (4.6, 6.7); n = 73 |
| HBcrAg, log10 IU/ml | 7.9 (7.3, 8.3); n = 27 | 5.1 (4.3, 5.8); n = 43 | 6.2 (4.9, 7.8); n = 70 |
| ALT, U/L | 123 (80, 179); n = 38 | 116 (81, 234); n = 71 | 119 (81, 202); n = 109 |
Data are n (%) or median (IQR). Statistical tests performed are as follows: Fisher’s exact test for categorical data and the Wilcoxon rank-sum test for continuous data. ALT, alanine aminotransferase; HBcrAg, hepatitis B core-related antigen.