Table 2.

Correlation between peripheral viral biomarkers and total HBV+ liver burden.

HBeAg status	Peripheral viral biomarker	Baseline			Week 48			Week 240
		R value	p value	Adjusted p value	R value	p value	Adjusted p value	R value	p value	Adjusted p value
HBeAg+	HBsAg	0.195	0.361	0.629	0.116	0.589	0.748	0.279	0.15	0.355
	HBcrAg	0.638	0.002	∗0.027	0.349	0.202	0.396	0.05	0.815	0.896
	HBV DNA	0.654	0.001	∗0.018	0.619	0.032	0.139	NR	–	–
	HBV RNA	0.651	0.001	∗0.025	0.519	0.084	0.258	−0.016	0.949	0.971
HBeAg-	HBsAg	0.279	0.168	0.371	0.103	0.435	0.694	0.433	0.004	0.033∗
	HBcrAg	−0.101	0.682	0.835	−0.111	0.552	0.721	−0.008	0.971	0.97
	HBV DNA	−0.118	0.557	0.721	NR	–	–	NR	–	–
	HBV RNA	−0.163	0.48	0.719	−0.398	0.142	0.335	0.046	0.932	0.97

Bold text indicates statistical significance with adjusted p value. ∗Adjusted p <0.05 (Pearson’s correlation analysis; p values adjusted for false discovery rate using the Benjamini–Hochberg procedure). HBcrAg, hepatitis B core-related antigen; NR, not reported (owing to insufficient [<5] data points for analysis).