Table IV.
Target gene and pathway enrichment analysis of dysregulated miRs identified from microarray results.
| KEGG pathway | P-value | Number of miRs | Number of genes | Associated miR | Associated gene |
|---|---|---|---|---|---|
| Prion diseases | 1.28×10−9 | 9 | 14 | miR-6775-3p, miR-548am-5p, miR-6824-3p, miR-195-3p, miR-7111-3p, miR-3184-3p, miR-200c-3pa, miR-4695-3p, miR-6737-3p | EGR1, STIP1, IL1B, BAX, HSPA5, NCAM1, NCAM2, NOTCH1, PRKACG, PRNP, PRKX, C6, MAPK1, ELK1 |
| Proteoglycans in cancer | 2.18×10−7 | 26 | 90 | miR-7111-3p, miR-3646, miR-200c-3pa, miR-6824-3p, miR-6759-3p, miR-6794-3p, miR-548am-5p, miR-4728-3p, miR-3184-3p, miR-195-3p, miR-4695-3p, miR-885-5pa, miR-449c-3p, miR-6894-3p, miR-6775-3p, miR-6847-3p, miR-6737-3p, miR-6730-3p, miR-3935, miR-6804-3p, miR-4763-5p, miR-6776-3p, miR-1296-5p, miR-6756-3p, miR-6784-3p, miR-6511a-3p | FZD7, ESR1, PPP1CA, BRAF, PRKCA, STAT3, WNT16, WNT7A, SMAD2, CBL, CAMK2G, NRAS, PTCH1, CAV1, WNT5A, PPP1CC, PXN, ROCK2, FRS2, FZD6, RDX, IQGAP1, ITGA5, RAF1, WNT2B, WNT4, TIAM1, IGF1R, EGFR, TLR4, RHOA, PPP1R12B, CAV2, KRAS, FZD3, RRAS2, MSN, ITGB5, MAPK13, ANK2, RPS6KB2, COL21A1, HPSE, CAMK2A, PTK2, ITGAV, ANK3, FZD4, PPP1R12A, DCN, PLCG1, CASP3, PIK3R3, CCND1, CTNNB1, HIF1A, FLNB, PRKACG, FLNA, ITGA2, SOS1, PIK3CG, PTPN11, PRKX, DDX5, SRC, FGF2, LUM, PRKCB, IGF1, GAB1, AKT3, PLCE1, PIK3CA, SDC2, FN1, CDKN1A, PDPK1, VMP1, WNT9B, TWIST1, FGFR1, MAPK1, ITPR2, KDR, ELK1, WNT9A, ERBB4, RPS6KB1, CD44 |
| Oxytocin signaling pathway | 7.45×10−6 | 26 | 79 | miR-3646, miR-6894-3p, miR-548am-5p, miR-6847-3p, miR-200c-3pa, miR-6775-3p, miR-3935, miR-4728-3p, miR-4695-3p, miR-6737-3p, miR-1909-5pa, miR-6794-3p, miR-3184-3p, miR-6824-3p, miR-1296-5p, miR-7111-3p, miR-6730-3p, miR-6756-3p, miR-195-3p, miR-6759-3p, miR-6804-3p, miR-885-5pa, miR-6776-3p, miR-6784-3p, -miR-449c-3p, -miR-6511a-3p | PPP1CA, FOS, PRKCA, CACNG8, EEF2K, GUCY1B3, MYLK4, ADCY5, CAMK2G, CAMK4, NRAS, PRKAA2, CD38, ADCY2, RCAN1, CALM1, GUCY1A3, CACNB4, PPP1CC, ROCK2, MAP2K5, PPP3R1, RAF1, KCNJ14, EGFR, GNAI3, RHOA, PPP1R12B, KRAS, CALM2, CAMKK2, NFATC4, NPR1, CAMK2A, PPP3CA, RYR1, PLCB1, PPP1R12A, JUN, PIK3, R3CCND1, PPP3CB, PRKACG, CACNB1, PTGS2, PIK3CG, PRKX, OXTR, SRC, PRKAA1, CAMK1, KCNJ6, CACNA1, CPRKCB, PRKAB2, KCNJ2, GNAQ, PRKAG2, GUCY1A2, PIK3CA, CDKN1A, CACNG3, CACNA2D1, CACNB2, MEF2C, CAMK1D, NFATC3, MAPK1, ITPR2, KCNJ5, KCNJ3, ELK1, PLCB4, MYLK, PLA2G4C, GNAI1, PPP3R2, CACNB3, ADCY6 |
| Hippo signaling pathway | 4.56×10−5 | 26 | 63 | miR-449c-3p, miR-200c-3, pmiR-6759-3p, miR-6894-3p, miR-6743-3p, miR-3935, miR-6784-3p, miR-6804-3p, miR-548am-5p, miR-7111-3p, miR-4728-3p, miR-195-3p, miR-4763-5p, miR-4695-3p, miR-3646, miR-1909-5pa, miR-6847-3p, miR-885-5pa, miR-6775-3p, miR-6776-3p, miR-6794-3p, miR-6824-3p, miR-6737-3p, miR-6756-3p, miR-3184-3p, miR-6730-3p | FZD7, PPP1CA, GSK3B, WNT16, PARD6G, WNT7A, YAP1, SMAD2, YWHAE, PPP2R2C, PPP2CA, NF2, WNT5A, BMPR1B, YWHAG, PPP1CC, GLI2, FZD6, WNT2B, WNT4, MOB1, BYWHAB, TEAD3, AMOT, WWTR1, TP53BP2, FZD3, BMP8B, YWHAQ, LLGL2, FZD4, CCND1, SMAD4, CTNNB1, TP73, PPP2R2A, PPP2R1A, LLGL1, DLG3, FRMD6, SAV1, TEAD1, YWHAZ, GDF6, CSNK1E, BMPR1A, CTNNA3, LEF1, RASSF1, WNT9B, MOB1A, CTNNA2, LATS1, BMP7, FGF1, FBXW11, PPP2R1B, PARD6B, INADL, TGFBR2, WNT9A, BMPR2, TGFB3 |
| Adrenergic signaling in cardiomyocytes | 1.04×10−4 | 25 | 62 | miR-548am-5p, miR-6824-3p, miR-4695-3p, miR-3646, miR-4728-3p, miR-6730-3p, miR-6776-3p, miR-885-5pa, miR-6756-3p, miR-6759-3p, miR-6847-3p, miR-6894-3p, miR-3184-3p, miR-7111-3p, miR-195-3p, miR-6737-3p, miR-200c-3pa, miR-6794-3p, miR-6784-3p, miR-6511a-3p, miR-4763-5p, miR-449c-3p, miR-1909-5pa, miR-6775-3p, miR-3935 | PPP1CA, RAPGEF3, SCN7A, PRKCACA, CNG8, PPP2R5E, ATP1B2, ADCY5, TPM1, CAMK2G, ATP2B2, PPP2R3A, ADCY2, CALM1, AGTR1, PPP2R2C, PPP2CA, CREB5, CACNB4, PPP1CC, BCL2, PPP2R5D, GNAI3, PPP1R1A, CALM2, MAPK13, PPP2R5A, RAPGEF4, CREB1, CAMK2A, SCN5A, PLCB1, PPP2R5B, ACTC1, PIK3R3, PLN, PPP2R2A, PPP2R1A, PRKACG, CACNB1, SLC8A1, ATP1A4, PIK3CG, PRKX, PPP2R3C, CACNA1C, GNAQ, AKT3, PIK3CA, AGTR2, ATP2B4, CACNG3, CACNA2D1, ATP2A2, CACNB2, MAPK1, PPP2R1B, PLCB4, GNAI1, CACNB3, KCNE1, ADCY6 |
| Oocyte meiosis | 3.3×10−4 | 21 | 55 | miR-3646, miR-6756-3p, miR-6759-3p, miR-885-5pa, miR-200c-3pa, miR-6847-3p, miR-548am-5p, miR-7111-3p, miR-6824-3p, miR-6784-3p, miR-449c-3p, miR-6775-3p, miR-3184-3p, miR-6894-3p, miR-195-3p, miR-4728-3p, miR-4695-3p, miR-6776-3p, miR-6737-3p, miR-6794-3p, miR-6730-3p | SLKE, SPL1, PPP1CA, PPP2R5E, SMC1A, ADCY5, CCNB1, PGR, CAMK2G, YWHAE, ADCY2, CALM1, PPP2CA, CPEB4, YWHAG, PPP1CC, CDK2, BUB1, PP3R1, CPEB1, CUL1, PPP2R5D, YWHAB, IGF1R, PLCZ1, ANAPC1, CALM2, YWHAQ, PPP2R5A, CAMK2A, PPP3CA, PPP2R5B, AR, PPP3CB, CCNE2, PPP2R1A, PRKACG, CPEB2, YWHAZ, ANAPC7, PRKX, MAD2L1, ANAPC5, RPS6KA3, IGF1, CDC27, RBX1, CPEB3, MAPK1, ITPR2, FBXW11, PPP2R1B, FBXO43, PPP3R2, ADCY6 |
| Thyroid hormone signaling pathway | 5.3×10−4 | 24 | 56 | miR-4695-3p, miR-6776-3p, miR-548am-5p, miR-3646miR-6759-3p, miR-6784-3p, miR-4763-5p, miR-6894-3p, miR-200c-3pa, miR-3184-3p, miR-7111-3p, miR-885-5pa, miR-6824-3p, miR-1296-5p, miR-4728-3p, miR-6737-3p, miR-6756-3p, miR-6511a-3p, miR-195-3p, miR-6794-3p, miR-6775-3p, miR-6847-3p, miR-449c-3p, miR-6730-3p | ESR1, GSK3B, PRKCA, ATP1B2, MED13L, NRAS, RCAN1, RXRG, DIO2, RAF1, MED13, SLC16A10, WNT4, THRA, PLCZ1, NOTCH2, RCAN2, KRAS, NCOA3, GATA4, MED1, ITGAV, PLCB1, TBC1D4, NOTCH1, PLCG1, PIK3R3, CCND1, CTNNB1, HIF1APLN, PRKACG, NCOR1, ATP1A4, NCOA2, PIK3CG, HDAC2, PRKX, KAT2A, SRC, PRKCB, KAT2B, EP300, AKT3, SLC16A2, PLCE1, PIK3CA, PDPK1, PFKFB2, ATP2A2, STAT1, RXRB, MAPK1, PLCB4, NCOA1, SIN3A |
a
Validated miR. KEGG, Kyoto Encyclopedia of Genes and Genomes; miR, microRNA.