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. 2023 Feb 14;31:631–647. doi: 10.1016/j.omtn.2023.02.007

Figure 2.

Figure 2

Theoretical reconstruction of CD spectra for 22-mer, 25-mer, and 30-mer PMOs

Superposed are the CD profiles for the 22-mer (A), 25-mer (B), and 30-mer (C) PMOs obtained experimentally (black solid lines) and theoretically (red dashed lines). The snapshots of PMO structures generated in silico numbered I–III, which correspond to the most representative, highest-weight-solution conformations contributing to the ensemble average CD spectra, are shown in twister representation (blue line going through backbone) and in PaperChain representation (for nucleic bases).