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. Author manuscript; available in PMC: 2023 Mar 9.
Published in final edited form as: Microcirculation. 2021 Oct 21;28(8):e12733. doi: 10.1111/micc.12733

FIGURE 6.

FIGURE 6

Hyperpolarization to SP occurs through KCa channels. (A) Representative recording of Vm in an intact MA (+EC) demonstrates attenuation of SMC hyperpolarization to SP in the presence of KCa channel inhibitors charybdotoxin (ChTx; 10−7 M) + apamin (AP; 3 × 10−7 M). B) Summary data for Vm responses to SP in SMCs from intact MAs (+EC) studied at 37°C under control (from Figure 1) conditions and during KCa channel inhibition. (C) Summary data for Vm responses to SP for ECs within endothelial tubes studied at 32°C during the absence or presence of KCa channel inhibitors. Values are means ± SEM for n = 5 per group. B = baseline Vm. W = washout in control PSS. #p < 0.05 vs. baseline (prior to application of SP) Vm in vessels treated with ChTx + AP. †p < 0.05 vs. control