FIGURE 8.

Genetic deletion of K_ATP channels inhibits hyperpolarization to CGRP. (A) Representative recording of V_m from an EC within a MA endothelial tube of a mouse lacking K_ATP channels illustrates normal (wildtype) response to CGRP (10⁻¹⁰–10⁻⁶ M). (B) Summary data for responses to CGRP in SMCs of intact MAs (+EC) studied at 37°C from K_ATP^−/− vs. wildtype mice. (C) Summary data for responses to CGRP in endothelial tubes studied at 32°C from K_ATP^−/− vs. wildtype mice. Values are means ± SEM for n = 5 per group. B = baseline V_m. W = washout in control PSS. #p < 0.05 vs. baseline (prior to application of CGRP) V_m in K_ATP^−/− mice. *p < 0.05 EC vs. SMC V_m in K_ATP^−/− mice. ^†p < 0.05 vs. wildtype