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. Author manuscript; available in PMC: 2023 Mar 9.
Published in final edited form as: Microcirculation. 2021 Oct 21;28(8):e12733. doi: 10.1111/micc.12733

FIGURE 9.

FIGURE 9

KATP channel activation hyperpolarizes SMCs more than ECs. (A) Representative recording from an EC within a MA endothelial tube illustrates concentration-dependent hyperpolarization to pinacidil (10−9–10−5 M). (B) Summary data from SMCs of intact MAs (+EC) studied at 37°C in response to increasing concentrations of pinacidil. (C) Summary data for ECs within endothelial tubes studied at 32°C in response to increasing concentrations of pinacidil. Values are means ± SEM for n = 5 per group. B = baseline Vm. W = washout in control PSS. # p < 0.05 vs. baseline (prior to application of pinacidil) Vm. *p < 0.05 EC vs. SMC Vm