TABLE 1.
Parameter (unit of measurement) | Results for the
following mice groups:
|
|||||
---|---|---|---|---|---|---|
Control
|
Fasted
|
Refed
|
||||
Wild-type | UBR1−/− | Wild-type | UBR1−/− | Wild-type | UBR1−/− | |
Glucose (mg/dl) | 172 ± 9.6 | 152 ± 10.3c | 162 ± 10.4 | 128 ± 8.5c | 186 ± 12.5 | 149 ± 15.1c |
Triglycerides (mg/dl) | 56.8 ± 6.7 | 44.5 ± 5.1c | 44.7 ± 5.5 | 35.2 ± 4.7d | 61.0 ± 6.9 | 46.2 ± 5.8d |
Cholesterol (mg/dl) | 57.3 ± 4.5 | 53.1 ± 5.1 | 68.5 ± 5.2 | 70.5 ± 4.6 | 54.4 ± 4.3 | 54.2 ± 4.8 |
Albumin (g/dl) | 1.40 ± 0.17 | 1.27 ± 0.12e | 2.13 ± 0.25 | 1.44 ± 0.31c | NDb | ND |
Urea nitrogen (mg/dl) | 21.3 ± 4.3 | 16.3 ± 3.2d | 27.3 ± 5.1 | 20.5 ± 4.7e | ND | ND |
Total protein (g/dl) | 3.23 ± 0.41 | 3.02 ± 0.34 | 4.33 ± 0.57 | 3.34 ± 0.52 | ND | ND |
Sodium (mmol/liter) | 147 ± 1.3 | 148 ± 1.6 | 153 ± 1.5 | 153 ± 1.5 | 148 ± 1.7 | 149 ± 1.9 |
Potassium (mmol/liter) | 6.43 ± 0.12 | 6.57 ± 0.15 | 5.25 ± 0.12 | 5.45 ± 0.13 | 6.52 ± 0.15 | 6.48 ± 0.13 |
Chloride (mmol/liter) | 116 ± 1.6 | 116 ± 1.5 | 122 ± 1.4 | 124 ± 0.6 | 116 ± 1.7 | 117 ± 1.5 |
Calcium (mg/dl) | 7.47 ± 0.21 | 7.43 ± 0.23 | 8.15 ± 0.27 | 7.35 ± 0.21 | 7.18 ± 0.36 | 7.42 ± 0.26 |
Phosphorus (mg/dl) | 11.5 ± 0.46 | 12.4 ± 0.34c | 12.7 ± 0.48 | 13.4 ± 0.32d | 11.7 ± 0.51 | 12.1 ± 0.69 |
The experiments were performed twice (experiments 1 and 2), with 28 pairs of animals total. The blood was collected from 12 pairs before fasting (control), 8 pairs after 24 h of fasting (fasted), and 8 pairs after 24 h of fasting and 24 h of refeeding (refed).
ND, not determined.
P < 0.001.
P < 0.01.
P < 0.05.