| Polyethylene terephthalate
(PET) |
Gabapentin |
A composite of soy protein
isolate (SPI) and poly(ethylene terephthalate) (PET) hydrogel incorporated
with gabapentin was formulated. SPI was attached covalently on PET
fabric, for which graft polymerization of acrylic acid was done and
then the carboxyl groups on acrylic acid were activated via EDAC;
thereafter SPI was coated on the PET surface. In vitro cell culture
performed on NIH 3T3 mouse fibroblasts revealed the composite to be
biocompatible with no cell cytotoxicity. |
(70) |
| Bacterial nanocellulose/acrylic acid |
Human dermal fibroblasts |
A nonbiodegradable hydrogel
comprising bacterial cellulose and acrylic acid (BNC/AA) loaded with
human dermal fibroblasts (HDFs) was developed. It was established
that >50% HDFs could be transferred successfully within 24 h onto
the wound site. The hydrogel with HDFs unveiled faster wound healing
in the gene and protein study. |
(71) |
| Polyurethane
(PU) |
Curcumin |
A hybrid hydrogel using
polyethylene glycol-based Fmoc-FF peptide and polyurethane was synthesized
in which curcumin was encapsulated via self-assembly with Fmoc-FF
peptide by π–π stacking. This approach improved
the loading of curcumin to as high as 3.3 wt % and also provided its
sustained release. Further, curcumin loading into the hydrogel also
improved its mechanical properties from 4 to 10 kPa, which is similar
to natural tissues. Also, the hydrogel was injectable and had self-healing
property. The in vivo results represented improved cutaneous wound
healing in full-thickness skin defected model. |
(72) |
| Poly(ethylene glycol)-b-poly(propylene sulfide) |
Vemurafenib |
A star-shaped amphiphilic
block copolymer comprising poly(propylene sulfide) and poly(ethylene
glycol) was utilized to develop vemurafenib loaded hydrogel. The amphiphilic
polymer forms a physically stable hydrogel and efficiently dissolve
the hydrophobic drug (vemurafenib) at therapeutic doses. The star-shaped
polymer delivered the hydrophobic drug and also supported cell growth
at the wound site, reduced inflammation, and promoted the wound closure. |
(73) |
| Polyurethane-poly(acrylamide) (PU–PAAm) |
|
A self-adhesive and mechanically
flexible PU–PAAm hydrogel was developed to overcome the drawbacks
of commercial hydrogel dressings such as lack of flexibility and adhesiveness.
The PU plays a bridging role, which enhances IPN formation between
physically cross-linked PU with chemically cross-linked PAAm network.
A superior ductility and stretchability were endowed by the IPN hydrogel.
The animal study confirmed high biocompatibility and tissue regeneration
capacity of the developed hydrogel. |
(74) |
| Polyurethane-poly(vinyl alcohol) (PU–PVA)/layered double-hydroxide
nanocomposite hydrogel |
Enoxacin |
A stretchable
and biocompatible
double-carrier drug delivery system for wound healing was developed.
Mg–Al layered double hydroxide (LDH) was loaded with enoxacin,
and then the LDH–enoxacin nanoparticles were prepared and incorporated
into a PU–PVA network to fabricate a double-carrier drug delivery
system. The mechanical properties and biocompatibility of PU–PVA
hydrogel significantly improved due to incorporation of LDH–enoxacin
nanoparticles in the hydrogel. |
(75) |
