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. 2023 Mar 8;20:65. doi: 10.1186/s12974-023-02746-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Brain regions associated with peripheral inflammation markers. Graph depiction of the brain regions significantly correlated with peripheral inflammation markers, including A IL2; B IL-12p70; C IL-17A; D sCD30/TNFRSF8; and E TNF-α. The brain regions are mainly distributed in frontal–temporal–limbic areas. The significant brain regions are demonstrated on a 3D brain template using the Brain-Net viewer toolbox. Detailed information about the brain regions is shown in Table 2. L left, R right, InfFroOrb inferior frontal orbital, MidFroOrb middle frontal orbital, SupFroOrb superior frontal orbital, MedFroOrb medial frontal orbital, Rec rectus, Olf olfactory, SupMedFro superior medial frontal, InfFroOpe inferior frontal operculum, AntCin anterior cingulate, MidTemPo middle temporal pole, SupTemPo superior temporal pole, InfTem inferior temporal gyrus, SupTem superior temporal gyrus, Hip hippocampus, ParHip para-hippocampus, Ins insula, Put putamen, Amy amygdala