Table 1.
Clinical characteristics of luminal fistulizing CD patients at baseline
| Clinical characteristics | N, % (Total N = 26) |
|---|---|
| Demographic features | |
| Age, year | 27.5 (24–34) |
| Male | 21, 80.8% |
| Cigrette consumption | 6, 23.1% |
| Present smoker | 1, 3.8% |
| Former smoker | 5, 19.3% |
| Clinical features | |
| Montreal classification* | |
| A classification | |
| A1 | 7, 26.9% |
| A2 | 16, 61.5% |
| A3 | 3, 11.5% |
| L classification | |
| L1 | 6, 23.1% |
| L3 | 20, 76.9% |
| B classification | |
| B3 | 10, 38.5% |
| B2 + 3 | 16, 61.5% |
| P classification | |
| O | 12, 46.2% |
| P | 14, 53.8% |
| Features of fistula | |
| History of abdominal infection | 13, 50.0% |
| History of abdominal abscess | 6, 23.1% |
| Complex fistula** | 13, 50.0% |
| Multiple fistula tract | 11, 42.3% |
| Type of fistula | |
| Enteric fistula | 19, 73.1% |
| Enterovesical fistula | 6, 23.1% |
| Enterocutaneous/enteroumbilical fistula | 1, 3.8% |
| Entero-retroperitoneal fistula | 2, 7.7% |
| Location of fistula | |
| Ileum | 10, 38.5% |
| Colon | 3, 11.5% |
| Ileum and colon | 13, 50.0% |
| Complicated with abdominal infection | 13, 50.0% |
| Low body mass index (BMI < 18.5 kg/m2) | 8, 30.8% |
| Decreased serum albumin (Alb < 35 g/L) | 4, 15.4% |
| Elevated ESR*** | 11, 42.3% |
| Increased hsCRP level (hsCRP > 3 mg/L) | 17, 65.4% |
| Baseline disease activity | |
| Clinical remission | 4, 15.4% |
| Mild active | 9, 34.6% |
| Moderate active | 13, 50.0% |
| Severe active | 0, 0 |
| Imaging features (CT) | |
| Intestine stricturing | 14, 53.8% |
| Intestine wall thickening and strengthening | 16, 61.5% |
| Mesenteric vessel thickening | 7, 26.9% |
| Mesenteric lymph nodes enlarging | 18, 69.2% |
| MRI evaluation | 5, 3.8% |
| Baseline treatment | |
| Total elemental enteric nutrition feeding | 14, 53.8% |
| Glucocorticoids | 24, 92.3% |
| 5-Aminosalicylic acids | 23, 88.5% |
| Immunosuppressants | 13, 50.0% |
| Therapeutic drug monitoring and dose adjustment | 12, 46.2% |
*Montreal classification: A: age, A1: < 17 years, A2: 17–40 years, and A3: > 40 years; L: location affected, L1: ileum, L2: colon, L3: ileum and colon; B: behavior, B3: penetrating, B2 + 3 stricturing and penetrating, P: perianal lesions, O: no perianal lesion
**Complex fistula: defined as multiple fistula tract or abdominal abscess
***Elevated ESR: ESR > 20 mm/h for females, > 15 mm/h for males