Table 3.
Univariate and multivariate analyses for different prognostic factors for surgery-free survival in patients with luminal fistulizing CD
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Existence of complex fistula* | 4.11 | 1.01–16.71 | 0.047** | 4.32 | 0.85–21.93 | 0.104 |
| Disease activity at baseline* | 2.36 | 0.77–7.19 | 0.099 | 2.37 | 0.62–9.00 | 0.199 |
| Efficacy at 6 months* | 0.23 | 0.01–0.72 | < 0.001** | 0.08 | 0.01–0.46 | 0.010** |
| Sex | 1.51 | 0.25–9.14 | 0.596 | – | ||
| Cigrette consumption | 2.82 | 0.83–9.51 | 0.147 | – | ||
| Montreal classification-A | 3.06 | 0.63–14.74 | 0.519 | – | ||
| Montreal classification-L | 2.07 | 0.40–10.78 | 0.469 | – | ||
| Montreal classification-B | 1.70 | 0.40–7.19 | 0.493 | – | ||
| Montreal classification-p | 0.46 | 0.11–1.85 | 0.250 | – | ||
| Location of fistula | 4.47 | 0.34–58.09 | 0.218 | – | ||
| History of abdominal infection | 1.26 | 0.31–5.07 | 0.733 | – | ||
| History of abdominal abcess | 3.48 | 0.10–125.14 | 0.166 | – | ||
| Low BMI | 1.62 | 0.38–6.93 | 0.531 | – | ||
| Decreased serum albumin | 0.47 | 0.11–4.87 | 0.770 | – | ||
| Increased hsCRP | 1.26 | 0.28–5.76 | 0.765 | – | ||
| Elevated ESR | 0.34 | 0.09–1.37 | 0.147 | – | ||
| Intestine stricturing | 0.59 | 0.13–2.61 | 0.456 | – | ||
| Intestine wall thickening and strengthening | 0.60 | 0.12–2.96 | 0.469 | – | ||
| Mesenteric vessel thickening | 1.15 | 0.21–6.28 | 0.856 | – | ||
| Mesenteric lymph nodes enlarging | 0.97 | 0.19–5.06 | 0.972 | – | ||
| Theraputic drug monitoring and dose adjustment | 0.39 | 0.11–1.36 | 0.202 | – | ||
*These three variables were included in the multivariate model
**P < 0.05 is considered statistically significant