Fig 3.

Omega-3 fatty acids prevent surgery-induced blood–brain barrier disruption. Surgery induced significant dextran diffusion (a and b), a reduction of PODXL (c and d), and reduction of a pericyte marker (CD13) into the hippocampus (e and f). These changes were prevented by omega-3 fatty acid pretreatment. Data expressed as mean (standard deviation); ∗P<0.05; ∗∗P<0.01; ∗∗∗P<0.001; n=4 per group (for panel b, the quantification was performed in three different regions in the hippocampus per mouse). AQP4, aquaporin 4; C, control; DAPI, 4′,6-diamidino-2-phenylindole; PODXL, podocalyxin; Sx, surgery; Sx+Om, surgery+omega-3 fatty acids.