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. 2022 Jul 18;2(7):635–643. doi: 10.1038/s43587-022-00243-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, Higher global longitudinal phenotypic score indicates accelerated phenotypic aging trajectories. Higher annual increase in multimorbidity indicates faster accumulation of chronic diseases. b, Among 893 participants aged >60 years during follow-up, the group with global longitudinal phenotypic score >0 (red) includes participants who experienced accelerated phenotypic aging trajectories, showing higher mortality compared with those with global longitudinal phenotypic score ≤0 (black; unadjusted time ratio (95% CI) = 0.87 (0.80, 0.95), P = 0.001, by fitting of Weibull distribution.) Two-sided tests were used, and the displayed P value was not adjusted for multiple comparisons.

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