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. 2022 Jul 18;2(7):635–643. doi: 10.1038/s43587-022-00243-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022, corrected publication 2023

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Fig. 8 — Estimated age equivalence of a one-point difference in global cross-sectional phenotypic score for different functional outcomes, including cognitive function, physical function and multimorbidity. Age equivalence is a scaled regression coefficient (point estimates and 95% CIs) relating cross-sectional phenotypic score and rate of changes in functions and illustrates how many years older in functional age are individuals with one point higher in cross-sectional phenotypic scores. Number of participants: DSST, n = 922; memory, n = 922; executive function, n = 929; attention, n = 929; language, n = 929; visuospatial ability, n = 919; usual gait speed, n = 968; time to finish 400-m walk, n = 943; HABC SPPB, n = 968; multimorbidity index, n = 828; also see Supplementary Table 1b for more details.