Table 1.
Demographic, clinical and network characteristics of amyloid positive and negative individuals.
| Characteristics | Amyloid negative (n = 814) |
Amyloid positive (n = 384) |
p-value |
|---|---|---|---|
| Female, N (%) | 475 (58.4) | 198 (51.6) | 0.032 |
| Age, Mean ± SD | 64.8 ± 6.96 | 66.5 ± 7.37 | <0.001 |
| MMSE, mean ± SD | 28.7 ± 1.42 | 28.4 ± 1.92 | <0.001 |
| CDR = 0.5, N (%) | 115 (14.1) | 97 (25.3) | <0.001 |
| Total tau, Mean ± SD | 218 ± 75.2 | 226 ± 126 | 0.182 |
| Phospho tau, Mean ± SD | 18.3 ± 7.28 | 21.0 ± 14.7 | <0.001 |
| Network Density, Mean ± SD | 0.20 ± 0.01 | 0.19 ± 0.01 | <0.001 |
| Network Size, Mean ± SD | 7226.76 ± 624.08 | 7247.38 ± 666.45 | 0.602 |
| Network Degree, Mean ± SD | 1454.00 ± 135.43 | 1436.94 ± 144.72 | 0.047 |
| Network Betweenness Centrality, Mean ± SD | 6177.08 ± 550.33 | 6222.36 ± 585.85 | 0.193 |
| Network Path Length, Mean ± SD | 1.85 ± 0.02 | 1.86 ± 0.02 | <0.001 |
| Network Lambda, Mean ± SD | 1.03 ± 0.01 | 1.03 ± 0.01 | 0.220 |
| Network Clustering, Mean ± SD | 0.49 ± 0.02 | 0.48 ± 0.02 | <0.001 |
| Network Gamma, Mean ± SD | 1.35 ± 0.04 | 1.34 ± 0.05 | <0.001 |
| Network Small-World Coefficient, Mean ± SD | 1.31 ± 0.04) | 1.30 ± 0.05 | <0.001 |
Abbreviations: MMSE = Mini-mental state evaluation; CDR = Clinical dementia rating scale. Statistical differences between amyloid positive and negative individuals are reported.