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. Author manuscript; available in PMC: 2023 Mar 9.
Published in final edited form as: Addict Neurosci. 2023 Jan 10;5:100062. doi: 10.1016/j.addicn.2023.100062

Fig. 2. HIV gp120 exposure during early cocaine abstinence prevents the attenuation of cue-induced cocaine seeking by the D3R partial agonist MC-25–41.

Fig. 2.

(A) Timeline of experimental procedures. (B) Mean (± SEM) cocaine infusions earned for each qualifying cocaine self-administration (S.A.) session prior to any treatments and (C) mean (± SEM) active lever presses (ALPs) and inactive lever presses (ILPs) during a 1-hr cue-induced cocaine seeking test. There were no group differences during training prior to abstinence and gp120 treatment. After gp120 treatment and 21 days abstinence, MC-25–41 significantly attenuated cue-induced cocaine seeking relative to vehicle treatment in control rats. However, MC-25–41 failed to attenuate cocaine seeking in rats treated with subchronic i.c.v. gp120 during the first 5 days of abstinence. ∗p < 0.05 between ALPs and ILPs for each group; #p < 0.05 relative to active lever presses of all other groups. Error bars = SEM; n = 6–7/group.