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. Author manuscript; available in PMC: 2023 Mar 9.
Published in final edited form as: Addict Neurosci. 2023 Jan 10;5:100062. doi: 10.1016/j.addicn.2023.100062

Fig. 5. Cue-induced cocaine seeking correlates with NAc core neuroimmune signaling.

Fig. 5.

After gp120 exposure and protracted abstinence, rats were tested for cue-induced cocaine seeking, with some rats receiving an acute systemic injection of MC-25–41 (10 mg/kg, i.p.; red symbols) prior to testing. Active lever pressing during cue-induced cocaine seeking correlated positively with NAc core (A) IL-6, (B) MIP-1α/CCL3, (C) MIP-2/CXCL2, (D) VEGF, and (E) GM-CSF expression. In contrast, cocaine seeking correlated negatively with (F) fractalkine/CX3CL1 expression. Dashed lines = 95% confidence bands. n = 6–7/group.