Figure S2.
The node of Ranvier in the PNS of adult wildtype and Schwann cell-specific deleted Lgi3 mice. Representative images of nodes of Ranvier in the sciatic nerve of wild-type (WT) and Schwann cell-specific deleted Lgi3 mice (DhhCre:Lgi3LoxP/LoxP). Nerves were stained with Caspr antibodies in green to visualize the paranodal domains flanking the nodal gap and with either Lgi3, Kv1.1, Kv1.2, Adam23, Adam22, and Caspr2 antibodies to visualize the components of the juxtaparanodal Kv1 complexes. No differences in immunostaining between the two genotypes were observed.