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. 2023 Feb 24;220(5):e20221346. doi: 10.1084/jem.20221346

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© 2023 Nickerson et al.

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Figure 2. — ABC-like cell subsets are heterogeneous in expression of MBC markers and do not account for all CD80 and PD-L2 expression among B cells. (A) Representative CD11c and CD11b staining on CD19⁺ splenocytes from a 15.5-wk female MRL/lpr. (B) Representative staining of CD80 and PD-L2 among all CD19⁺ B cells (far right) or indicated CD11c and/or CD11b B cell subsets. (C) Quantification of CD80 single-positive B cells among indicated subsets. (D) Quantification of CD80⁺ PD-L2⁺ B cells among indicated subsets. (E) Representative staining of CD73 in indicated B cell subsets. (F) Quantification of CD73⁺ cells among indicated B cell subsets. (G) Representative staining of CD11c and CD11b among total CD80⁺PD-L2⁻ (top) or CD80⁺PD-L2⁺ (bottom) B cells. Summary data are pooled from five (C and D) or seven (F) independent experiments and include both male and female mice. Horizontal lines indicate medians. Statistical comparisons by two-tailed Mann-Whitney; *P < 0.05; **P < 0.01; ****P < 0.0001.