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. 2023 Feb 24;220(5):e20221346. doi: 10.1084/jem.20221346

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© 2023 Nickerson et al.

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Figure 4. — ABC-like cells are proliferative. (A) B cells of the indicated subsets were stained for Ki67 by flow cytometry. (B) MRL/lpr mice were provided BrdU in drinking water for the indicated durations and splenocytes were analyzed for incorporation of label. Data are pooled from four experiments. (C) MRL/lpr mice were provided BrdU in drinking water for 9 d and returned to normal drinking water for the indicated durations. BrdU incorporation was normalized to the average amount of label observed on d9 within each experiment for each subset. Data are pooled from two experiments. (D) CD11c-DTR⁺ MRL/lpr (red squares) or littermate controls (black circles) were given 8 ng/kg DT i.p. at 7, 4, or 1 d prior to analysis or left untreated. Splenocytes were analyzed for the presence of indicated cell types by flow cytometry. Statistics in A and D by two-tailed Mann-Whitney; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.