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. 2023 Feb 23;14:1069485. doi: 10.3389/fphys.2023.1069485

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Copyright © 2023 Candido, Perego, Ceroni, Metzger, Colquhoun and Michelini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of BBB permeability within the PVN, NTS, and RVLM of sedentary (S) and trained (T) SHR and Wistar rats. Left photomicrographs show the capillary network (Rhodamine-70kDa, red), the FITC-10kDa leakage (green) into the brain parenchyma and the colocalization of both inside capillaries (white) within the three autonomic areas. Scale bars = 50 μm. Right bar graphs depict the effects of hypertension and exercise training on the BBB leakage into the PVN, NTS and RVLM. Values are means of 5-7 slices/area/rat, 3-4 rats/group. Comparisons made by 2-way factorial ANOVA. PVN: group F (1,12) = 23.57, p < 0.001, condition F (1,12) = 23.98, p < 0.001, group x condition F (1,12) = 13.06, p = 0.004; NTS: group F (1,12) = 5.96, p = 0.031, condition F (1,12) = 28.53, p < 0.001, group x condition F (1,12) = 6.27, p = 0.028; RVLM: group F (1,10) = 3.40, p = 0.090, condition F (1,10) = 19.79, p < 0.001, group x condition F (1,10) = 3.85, p = 0.073. Significances (p < 0.05) are * vs. respective Wistar group; † vs. respective S control.