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. 2023 Feb 23;14:1069485. doi: 10.3389/fphys.2023.1069485

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Copyright © 2023 Candido, Perego, Ceroni, Metzger, Colquhoun and Michelini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of hypertension and exercise training on transcellular vesicles number/capillary. (A). Electron micrographs depicting the transcellular vesicles (yellow arrows) being formed in the luminal and abluminal borders of the endothelial cell within PVN capillaries of sedentary (S) and trained (T) SHR and Wistar rats. Scale bars = 200 nm Right panels show the quantification of vesicle number in the 4 experimental groups at the end of protocols within the PVN (B), NTS (C), and RVLM (D) capillaries. n = 9–11 capillaries/rat, 3 rats/group. Comparisons made by 2-way factorial ANOVA. Significances (p < 0.05) are * vs. respective Wistar group; † vs. respective S control.