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. 2023 Feb 23;14:1069485. doi: 10.3389/fphys.2023.1069485

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Copyright © 2023 Candido, Perego, Ceroni, Metzger, Colquhoun and Michelini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of hypertension and exercise training on caveolin-1 content within the PVN. (A). Photomicrographs show caveolin-1 expression (green) within PVN capillaries (RECA-1, red) and the colocalization of both (yellow) in sedentary (S) and trained (T) SHR and Wistar rats. Scale bar = 50 μm, 3V, third ventricle. (B). Comparison of PVN caveolin-1 immunofluorescence in the 4 experimental groups at the end of protocols. n = 5–7 slices/rat, 6 rats/group. Comparisons made by 2-way factorial ANOVA: group F (1,20) = 13.36, p = 0.002, condition (F1,20) = 19.03, p < 0.001, group x condition (F1,20) = 13.74, p = 0.001. Significances (p < 0.05) are * vs. respective Wistar group; † vs. respective S control.