Table 1.

General description and outcomes of the studies included in the meta-analysis.

Authors, publication year	No of participants (studies)	Risk factors	Diagnostic criteria	Mammography				MRI				Mammography + MRI
				N screens	Positive outcomes	Detected cancers		N screens	Positive outcomes	Detected cancers		N screens	Positive outcomes	Detected cancers
						N	Per 1000			N	Per 1000			N	Per 1000
Berg et al 2012[14]	7473 (Prospective cohort)	BRCA mutation; personal history of breast cancer; history of prior chest irradiation	BI–RADS (3–5) + Biopsy	7473	759	33	4.4	612	159	9	14.7	612	191	16	26.1
Bigenwald et al 2008[15]	505 (Prospective cohort)	BRCA mutation; family history of breast or ovarian cancer	Biopsy	505	NR	11	21.8	505	NR	41	81.2	NR	NR	NR	NR
Chiarelli et al 2020[12]	20,053 (Prospective cohort)	BRCA mutation; family history of breast cancer; history of prior chest irradiation	Biopsy	20,053	2003	109	5.4	20,053	3121	263	13.1	2,0053	4472	280	14.0
Cho et al 2017[16]	2065 (Prospective cohort)	Personal history of breast cancer	BI–RADS (3–5) + Biopsy	2065	91	9	4.4	2065	221	15	7.3	2065	284	17	8.2
Lehman et al 2007[17]	171 (Prospective cohort)	BRCA mutation; family history of breast or ovarian cancer	BI–RADS (3–5) + Biopsy	171	17	2	11.7	171	41	6	35.1	171	51	6	35.1
Guindalini et al 2019[18]	1223 (Prospective cohort)	BRCA mutation; personal history of breast cancer at age < 35 yr or family history of breast cancer; history of prior chest irradiation at age < 30 yr	Biopsy	1223	34	7	5.7	2111	87	15	7.1	2209	106	16	7.2
Kriege et al 2006[19]	4134 (Prospective cohort)	Familial or genetic predisposition, cumulative lifetime risk of breast cancer > 15%	BI–RADS (3–5) + Biopsy	4134	225	18	4.4	4134	452	32	7.7	4134	448	40	9.7
Kuhl et al 2010[20]	1679 (Prospective cohort)	BRCA mutation; familial and personal history of breast cancer	BI–RADS (4–5) + Biopsy	1679	23	9	5.4	1679	52	25	14.9	1679	67	27	16.1
Leach et al 2005[21]	1881 (Prospective cohort)	BRCA or TP53 mutation; family history of breast or ovarian cancer; family history of classic Li-Fraumeni syndrome	BI–RADS (3–5)	1881	135	14	7.4	1881	371	27	14.4	1881	371	33	17.5
Lehman et al 2005[22]	367 (Prospective cohort)	BRCA mutation; family history of breast cancer	BI–RADS (4–5) + Biopsy	367	8	1	2.7	367	31	4	10.9	367	38	4	10.9
Ng et al 2013[23]	338 (Prospective cohort)	Chest irradiation at age ≤ 35 yr	BI–RADS (3–5) + Biopsy	338	NR	13	38.5	338	NR	12	35.5	338	NR	18	53.3
Podo et al 2002[24]	781 (Prospective cohort)	BRCA mutation; family history of breast cancer	BI–RADS (4–5) + Biopsy	781	NR	13	16.6	781	NR	24	30.7	781	NR	40	51.2
Riedl et al 2015[25]	1365 (Prospective cohort)	BRCA mutation; family history of breast cancer	BI–RADS (4–5) + Biopsy	1365	53	15	11.0	1365	183	36	26.4	1365	204	38	27.8
Sardanelli et al 2011[26]	1095 (Prospective cohort)	BRCA mutation; family and personal history of breast or ovarian cancer	BI–RADS (4–5) + Biopsy	1095	35	25	22.8	1045	75	42	40.2	1024	77	41	40.0
Stoutjesdijk, et al 2001[27]	262 (retrospective cohort)	BRCA mutation; family and personal history of breast or ovarian cancer	BI–RADS (3–5) + Biopsy	262	15	5	19.1	258	30	13	50.4	75	21	12	160.0
Vreemann et al 2018[28]	6553 (retrospective cohort)	BRCA mutation	BI–RADS (4–5) + Biopsy	6553	215	66	10.1	6553	399	112	17.1	6553	502	125	19.1
Weinstein et al 2009[29]	569 (Prospective cohort)	BRCA mutation; personal history of breast cancer, LCIS or atypical hyperplasia; history of prior chest irradiation	Biopsy	569	72	7	12.3	571	129	12		571	NR	19	33.3
Weinstock et al 2015[30]	571 (Prospective cohort)	Personal history of breast cancer	BI–RADS (4–5) + Biopsy	571	NR	3	5.3	571	NR	8	NR	571	NR	11	19.3

BI–RADS = breast imaging reporting and data system, BRCA = breast cancer susceptibility gene, LCIS = lobular carcinoma in situ, NR = not report.