Fig 7. Success probabilities for the treatment arm with respect to the response rate for endpoint 1 (E1_Suc_Rate; columns), the response rate for endpoint 2 (E2_Suc_Rate; rows), the correlation between the two endpoints (x-axis), the type of data sharing used (point shape), the level of evidence required (colour) and the planned sample size per cohort (left panel 150 and right panel 250).

The blue horizontal line marks 80% as a common target for the power and the red horizontal line marks 10% as a common target for type 1 error in early phase clinical trials. Level of evidence required refers to how many of the Bayesian efficacy rules specified in section 2.2 need to simultaneously hold for a treatment to be declared efficacious.