Table 4. Incidence of morbidities by cGVHD status among patients who survived ≥6 months post-HSCT.
| Crude incidence rates per 1000-person years (95% CI) | Adjusted incidence rate ratios (95% CI) | ||||
|---|---|---|---|---|---|
| Description of Disease/Disorder | Non-cGVHD | Mild cGVHD | Moderate-Severe cGVHD | Non-cGVHD vs Moderate-Severe cGVHD | Mild cGVHD vs Moderate-Severe cGVHD |
| Certain infectious and parasitic diseases | 215 (191–242) | 167 (146–190) | 243 (224–264) | 0.76 (0.52–1.03) | 0.69 (0.53–0.91) |
| Endocrine, nutritional and metabolic diseases | 63 (51–78) | 140 (121–162) | 158 (143–175) | 0.41 (0.22–0.75) | 0.90 (0.47–1.41) |
| Mental, behavioural, and neurodevelopmental disorders | 40 (30–52) | 95 (80–113) | 112 (99–126) | 0.36 (0.14–0.74) | 0.74 (0.30–1.64) |
| Diseases of the nervous system | 26 (18–36) | 31 (23–42) | 60 (51–71) | 0.44 (0.27–0.68) | 0.50 (0.31–0.76) |
| Diseases of the eye and adjacent organs | 230 (205–258) | 341 (311–374) | 705 (672–739) | 0.32 (0.23–0.42) | 0.49 (0.34–0.68) |
| Diseases of the ear and mastoid process | 48 (37–62) | 33 (25–45) | 61 (51–71) | 0.79 (0.40–1.25) | 0.48 (0.28–0.74) |
| Diseases of the circulatory system | 67 (54–83) | 100 (84–119) | 177 (160–194) | 0.32 (0.22–0.47) | 0.53 (0.36–0.78) |
| Diseases of the respiratory system | 152 (132–175) | 167 (146–190) | 272 (252–294) | 0.49 (0.36–0.63) | 0.59 (0.45–0.75) |
| Diseases of the digestive system | 86 (71–103) | 117 (100–137) | 229 (211–249) | 0.39 (0.27–0.52) | 0.49 (0.35–0.65) |
| Diseases of the cutaneous and subcutaneous tissue | 112 (95–132) | 93 (78–111) | 148 (133–164) | 0.73 (0.58–0.94) | 0.60 (0.45–0.77) |
| Diseases of the musculoskeletal system and connective tissue | 91 (76–109) | 140 (121–161) | 236 (217–256) | 0.39 (0.24–0.55) | 0.62 (0.44–0.84) |
| Diseases of the genitourinary system | 196 (173–222) | 231 (206–258) | 255 (235–276) | 0.75 (0.59–0.94) | 0.83 (0.63–1.05) |
| Injury, poisoning, and certain other consequences of external causesa | 155 (134–177) | 255 (229–284) | 1001 (961–1041) | 0.17 (0.11–0.23) | 0.23 (0.18–0.29) |
Morbidities are categorised by International Classification of Diseases code. Incidences within the disease group for the same month are counted separately. Generalised linear Poisson model was used with person-years as offset.
aThis class (S00-T98) also includes GVHD.