Table 1. Study hypotheses.

Hypothesis Number	Analysis Type	Conditions	Zoom Level	Expected Pattern	Clinical Rationale
1	Tonic	Low vs. High Difficulty Images	Low magnification (1× to 5×): exploration	Larger pupil diameter during more difficult interpretation.	More visually or cognitively demanding feature interpretation.
2	Tonic	Low vs. High Magnification Zoom	Low (1× to 5×) and High (6× to 60×) magnification	Larger pupil diameter during exploration (low magnification) vs. exploitation (high magnification).	Low magnification visual scan of image to find regions to interrogate.
3	Phasic	All Images	Shift from low to high magnification: shift to exploitation	Pupil diameter increase upon zoom-in event.	Shift to high magnification to interrogate concerning features.
4	Phasic	All Images	Shift from high to low magnification: shift to exploration	Pupil diameter is higher before zoom-out event.	Features interpreted, ready to shift back to low magnification scanning.

The four primary hypotheses of our study, clinical rationale for the hypotheses, and how the hypotheses were tested.